Bacteria in oral carcinogenesis

Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria

Oral cancer, primarily oral squamous cell carcinoma (OSCC), continues to be a major global health problem with high incidence and low survival rates. While the major risk factors for this malignancy, mostly lifestyle related, have been identified, around 15% of oral cancer cases remain unexplained. In light of evidence implicating bacteria in the aetiology of some cancer types, several epidemio...

Osteopontin and oral carcinogenesis

down-regulation of osteopontin and breast tumour progression in vivo is highly interesting [1]. Recent studies indicate a close association between not only breast cancer and osteopontin but other systemic malignancies as well. Studies over the past few years have especially shown a strong relationship between osteopontin expression and oral carcinogenesis. For instance, Devoll et al. in a rece...

HPV infection and oral carcinogenesis.

Innate Immunity and Oral Carcinogenesis

Oral cancer is initiated from stem cells of the basal layer of the epithelium that have acquired genetic alterations [2-5]. Accumulation of genetic alterations and environmental factors drive the development of tumors to highly malignant lesions, a process involving not only tumor cells but also many other non-neoplastic cells, particularly infiltrating immune cells, in the tumor microenvironme...

Overexpression of PAX5 in oral carcinogenesis.

The oncogenic transcription factor PAX5 is an important developmental regulator and is implicated in the pathogenesis of several malignancies. The PAX5 gene is involved in medulloblastoma, non-Hodgkin's lymphoma, transitional cell carcinoma of the bladder, neuroblastoma, breast cancer and SCC. In the current study, to determine the potential involvement of PAX5 in oral squamous-cell carcinoma (...